Dichloromethane → Dimethyl 2-(4-chloro-2-fluorophenyl)piperidine-1,4-dicarboxylate

HRID 107781Notes

Reaction equation

HRID 107781 reaction equation
[C:28]([O:29][CH3:30])(=[O:31])[Cl:32].[CH:19]([N:20]([CH2:21][CH3:22])[CH:23]([CH3:24])[CH3:25])([CH3:26])[CH3:27].[Cl:1][c:2]1[cH:3][c:4]([F:18])[c:5]([CH:8]2[NH:9][CH2:10][CH2:11][CH:12]([C:14](=[O:15])[O:16][CH3:17])[CH2:13]2)[cH:6][cH:7]1.[Cl:33][CH2:34][Cl:35]>>[Cl:1][c:2]1[cH:3][c:4]([F:18])[c:5]([CH:8]2[N:9]([C:28]([O:29][CH3:30])=[O:31])[CH2:10][CH2:11][CH:12]([C:14](=[O:15])[O:16][CH3:17])[CH2:13]2)[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 6586Methyl chloroformateHCID 81531DiisopropylethylamineHCID 66732030Methyl 2-(4-chloro-2-fluorophenyl)piperidine-4-carboxylate

Product 1

HCID 66734801Dimethyl 2-(4-chloro-2-fluorophenyl)piperidine-1,4-dicarboxylate

Sources & evidence

ORD record
ord-6f15a79e86a04ed78b1ce5883f37c05f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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