反应详情

A mixture of 5,6-dimethyl-2-(4-methylphenyl)-3H-pyrimidin-4-one (6 g) and phosphorus oxychloride (40 ml) was refluxed for 2 hours. Excess phosphorus oxychloride was removed under reduced pressure, ice added to the residue, and the mixture extracted with methylene chloride, the organic layer washed with brine, dried over sodium sulfate, the solvent evaporated under reduced pressure, to yield 6.2 g of 4,5-dimethyl-6-chloro-2-(4-methylphenyl)pyrimidine, m.p. 165° C.

1. temperaturewas refluxed for 2 hours
2. customExcess phosphorus oxychloride was removed under reduced pressure, ice
3. additionadded to the residue
4. extractionthe mixture extracted with methylene chloride
5. washthe organic layer washed with brine
6. dry with materialdried over sodium sulfate
7. customthe solvent evaporated under reduced pressure