HCID 10704523, compound → 1-(4-trifluoromethylphenyl)imidazolidin-2-one

HRID 1077899Notes

Reaction equation

HRID 1077899 reaction equation
[F:1][C:2]([F:16])([F:15])[C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH:13]=[CH:12][NH:11][C:10]2=[O:14])=[CH:5][CH:4]=1>C(O)(=O)C.[C].[Pd]>[F:16][C:2]([F:1])([F:15])[C:3]1[CH:4]=[CH:5][C:6]([N:9]2[CH2:13][CH2:12][NH:11][C:10]2=[O:14])=[CH:7][CH:8]=1

Participants

4

Reactant 1

HCID 10704523HCID 10704523, compound

Product 1

HCID 106809511-(4-trifluoromethylphenyl)imidazolidin-2-oneYield 81.9%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 176Acetic AcidSolvent

Procedure

1-(4-Trifluoromethylphenyl)-2(1H,3H)-imidazolone (1.15 g) was dissolved in 20 ml of acetic acid. 10% Palladium-carbon (0.3 g) was added thereto and the mixture was stirred under a hydrogen stream for six hours. The catalyst was filtered off, the solvent was distilled off and the residue was recrystallized from ethyl acetate-diisopropyl ether to give 0.95 g of 1-(4-trifluoromethylphenyl)-2-imidazolidinone as colorless prisms.

Workup

  1. filtrationThe catalyst was filtered off
  2. distillationthe solvent was distilled off
  3. customthe residue was recrystallized from ethyl acetate-diisopropyl ether

Sources & evidence

ORD record
ord-bfb5d0481829473cb2ea3ef28bac0159
Source dataset
uspto-grants-1996_08
Patent number
US05545652

Reaction notes

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