反应详情

温度

80 °C

A glacial acetic acid (15 mL) solution containing Pd(OH)2 /C and 1-benzyl-4-(1-indolyl)-piperidine was placed under an H2 atmosphere. The reaction temperature was raised to 80° C. After 1 hour, the reaction was cooled to room temperature and filtered. The filtrate was made basic (pH 8-9) with saturated NaHCO3, and extracted with methylene chloride. The extract was washed with water, dried, and concentrated. This material was sufficiently pure for further reactions giving 1.09 g (80% yield) of the title compound.

1. temperaturethe reaction was cooled to room temperature
2. filtrationfiltered
3. extractionextracted with methylene chloride
4. washThe extract was washed with water
5. customdried
6. concentrationconcentrated