Trifluoroacetic acid → HCID 19430534, compound

HRID 1077976Notes

Reaction equation

HRID 1077976 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12]2[CH:27]=[C:26]([C:28]([F:31])([F:30])[F:29])[CH:25]=[CH:24][C:13]=2[O:14][C:15]2[CH:23]=[CH:22][CH:21]=[CH:20][C:16]=2[C:17]([O-:19])=[O:18])(=[O:10])=[O:9])=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>C(Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12]2[CH:27]=[C:26]([C:28]([F:31])([F:29])[F:30])[CH:25]=[CH:24][C:13]=2[O:14][C:15]2[CH:23]=[CH:22][CH:21]=[CH:20][C:16]=2[C:17]([OH:19])=[O:18])(=[O:10])=[O:9])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 19430582HCID 19430582, compound

Product 1

HCID 19430534HCID 19430534, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2-[2-(4-Chlorophenylsulfonamido)-4-trifluoromethylphenoxy]benzoate was mixed in methylene chloride (5 mL) at 0° C. for 5 min. Trifluoroacetic acid (5 mL) was then added dropwise to the cold mixture and stirred for 2 h. The solvents were evaporated and the residue flash chromatographed (silica gel, ethyl acetate/hexane/formic acid) to yield the title compound; mp 164° C.

Workup

  1. customThe solvents were evaporated
  2. customthe residue flash chromatographed (silica gel, ethyl acetate/hexane/formic acid)

Sources & evidence

ORD record
ord-af2ee335860d430c988c70562362971b
Source dataset
uspto-grants-1996_08
Patent number
US05545669

Reaction notes

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