Levofloxacin → Levofloxacin monohydrate

HRID 1077999Notes

Reaction equation

HRID 1077999 reaction equation
[CH3:1][C@@H:2]1[N:23]2[C:6]3[C:7]([C:19]([C:21]([C:24]([OH:26])=[O:25])=[CH:22]2)=[O:20])=[CH:8][C:9]([F:18])=[C:10]([N:11]2[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]2)[C:5]=3[O:4][CH2:3]1>O>[OH2:4].[F:18][C:9]1[C:10]([N:11]2[CH2:12][CH2:13][N:14]([CH3:17])[CH2:15][CH2:16]2)=[C:5]2[O:4][CH2:3][C@H:2]([CH3:1])[N:23]3[CH:22]=[C:21]([C:24]([OH:26])=[O:25])[C:19](=[O:20])[C:7]([CH:8]=1)=[C:6]23

Participants

3

Reactant 1

HCID 149096Levofloxacin

Product 1

HCID 178438Levofloxacin monohydrateYield 169.2%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

5 g of crude levofloxacine crystals were added to 50 ml of water and then treated in the same manner as described in Example 4. Thus 4.44 g of (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]-benzoxazine-6-carboxylic acid monohydrate was obtained.

Workup

  1. additiontreated in the same manner

Sources & evidence

ORD record
ord-1ac20a5b5b694ee9b5be577a645ed59f
Source dataset
uspto-grants-1996_08
Patent number
US05545737

Reaction notes

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