Levofloxacin → Levofloxacin monohydrate

Participants

Reaction Steps

5 g of crude levofloxacine crystals were added to 50 ml of water and then treated in the same manner as described in Example 4. Thus 4.44 g of (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]-benzoxazine-6-carboxylic acid monohydrate was obtained.

Provenance & Evidence