HCID 20086705, compound → HCID 178440055, compound

HRID 1078046Notes

Reaction equation

HRID 1078046 reaction equation
[CH2:1]([C:3]1[N:4]=[C:5]([CH2:59][CH2:60][CH3:61])[N:6]([CH2:22][C:23]2[CH:28]=[CH:27][C:26]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=3[C:35]3[N:39](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[N:38]=[N:37][N:36]=3)=[CH:25][CH:24]=2)[C:7]=1[C:8]([O:10][CH2:11][CH2:12][C:13]([NH:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:14])=[O:9])[CH3:2]>CO>[CH2:1]([C:3]1[N:4]=[C:5]([CH2:59][CH2:60][CH3:61])[N:6]([CH2:22][C:23]2[CH:28]=[CH:27][C:26]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=3[C:35]3[NH:39][N:38]=[N:37][N:36]=3)=[CH:25][CH:24]=2)[C:7]=1[C:8]([O:10][CH2:11][CH2:12][C:13]([NH:15][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)=[O:14])=[O:9])[CH3:2]

Participants

3

Reactant 1

HCID 20086705HCID 20086705, compound

Product 1

HCID 178440055HCID 178440055, compoundYield 64.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 0.05 g N-phenyl-2-(aminocarbonyl)ethyl 4-ethyl-2-propyl-1-[[2'-(N-triphenylmethyl(tetrazol-5-yl) )biphenyl-4-yl]methyl]imidazole-5-carboxylate in 2.5 mL MeOH was refluxed overnight under N2. The reaction was evaporated to dryness and the residue immediately purified by flash chromatography with 0-5% MeOH/CHCl3 gradient to give 0.0226 g of pure product.

Workup

  1. customThe reaction was evaporated to dryness
  2. customthe residue immediately purified by flash chromatography with 0-5% MeOH/CHCl3 gradient

Sources & evidence

ORD record
ord-3bea80d1fe2c45809953e632a64d9384
Source dataset
uspto-grants-1996_08
Patent number
US05545651

Reaction notes

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