Oxalyl chloride → HCID 22910224, compound

HRID 1078106Notes

Reaction equation

HRID 1078106 reaction equation
[CH3:1][CH:2]([CH3:21])[CH2:3][CH2:4][NH:5][C:6](=[O:20])[C:7]([F:19])([F:18])[CH:8]([OH:17])[CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.C(Cl)(=O)C(Cl)=O>CS(C)=O>[CH3:1][CH:2]([CH3:21])[CH2:3][CH2:4][NH:5][C:6](=[O:20])[C:7]([F:18])([F:19])[C:8](=[O:17])[CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 22910065HCID 22910065, compound

Product 1

HCID 22910224HCID 22910224, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

According to the procedure of Thaisrivongs et. al. (J. Med. Chem., 1986, 29, 2080), the resultant compound of Example 46 was treated with dimethylsulfoxide and oxalyl chloride to give the desired compound.

Sources & evidence

ORD record
ord-0160774790dd47d7b83447a54b612bdb
Source dataset
uspto-grants-1996_08
Patent number
US05545750

Reaction notes

Loading…