HRID1078113

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C(O)C(Cc1ccccc1)NC(=O)OC(C)(C)C

HCID3011021

未命名化合物

HCID22281272

未命名化合物

PRODUCTS

生成物

结构：CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C(O)C(N)Cc1ccccc1

HCID22864446

未命名化合物

收率 100%

PROCEDURE

实验过程

Using the procedure of Example 56 with the resultant compound of Example 55 gave, after silica gel chromatography using methanol/isopropylamine/chloroform, the desired compound (RF 0.3; 2.5% methanol/2% isopropylamine/chloroform) in 100% yield, m.p. 158°-160° C. Mass spectrum (M+H)+ =504.

WORKUP

后处理

customgave

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bb5717d605af4b189bfaa0932fcd9cfa
来源数据集: uspto-grants-1996_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05545750
来源说明: uspto-grants-1996_08

反应 SMILES

C(OC([NH:8][CH:9]([CH:17]([OH:44])[CH:18]([NH:26][C:27](=[O:43])[C@H:28]([CH:40]([CH3:42])[CH3:41])[NH:29][C:30]([O:32][CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)=[O:31])[CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=O)(C)(C)C.CO.C(N)(C)C.C(Cl)(Cl)Cl>>[NH2:8][CH:9]([CH:17]([OH:44])[CH:18]([NH:26][C:27](=[O:43])[C@H:28]([CH:40]([CH3:42])[CH3:41])[NH:29][C:30]([O:32][CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)=[O:31])[CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH2:10][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1