tert-butyl N-[1-benzyl-3-[[(2S)-2-(benzyloxycarbonylamino)-3-methyl-butanoyl]amino]-2-hydroxy-4-phenyl-butyl]carbamate → 2Amino-4-(Cbz-valinyl-amino)-1,5-diphenyl-3hydroxypentane

Participants

Reaction Steps

Using the procedure of Example 56 with the resultant compound of Example 55 gave, after silica gel chromatography using methanol/isopropylamine/chloroform, the desired compound (RF 0.3; 2.5% methanol/2% isopropylamine/chloroform) in 100% yield, m.p. 158°-160° C. Mass spectrum (M+H)+ =504.

Provenance & Evidence