1-Chloro-4-(p-fluorophenyl)-1-silacyclohexane → HCID 178455750, compound

HRID 1078167Notes

Reaction equation

HRID 1078167 reaction equation
Cl[SiH:2]1[CH2:7][CH2:6][CH:5]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)[CH2:4][CH2:3]1.[CH2:15]([C@H:17]1[CH2:22][CH2:21][C@H:20]([CH2:23][CH2:24][Mg]Br)[CH2:19][CH2:18]1)[CH3:16].Cl[SiH]1CCC(C2C=CC(F)=C(F)C=2)CC1.C([C@H]1CC[C@H](CC[Mg]Br)CC1)CCC>>[CH2:15]([C@H:17]1[CH2:22][CH2:21][C@H:20]([CH2:23][CH2:24][Si@H:2]2[CH2:7][CH2:6][C@H:5]([C:8]3[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=3)[CH2:4][CH2:3]2)[CH2:19][CH2:18]1)[CH3:16]

Participants

5

Reactant 4

HCID 1238667801-Chloro-4-(p-fluorophenyl)-1-silacyclohexaneHCID 1317191281-Chloro-4-(3,4-difluorophenyl)-1-silacyclohexaneHCID 178445618HCID 178445618, compoundHCID 178455748HCID 178455748, compound

Product 1

HCID 178455750HCID 178455750, compound

Procedure

The preparation was conducted in the same manner as in Example 18, except that 22.8 g (100 mmol) of 1-chloro-4-(p-fluorophenyl)-1-silacyclohexane and 2-(trans-4-ethylcyclohexyl) ethylmagnesium bromide were used instead of 24.6 g (100 mmol) of 1-chloro-4-(3,4-difluorophenyl)-1-silacyclohexane and 2-(trans-4-n-butylcyclohexyl)ethylmagnesium bromide.

Sources & evidence

ORD record
ord-f6debdbb0fdd457cb3a055f37d5450ee
Source dataset
uspto-grants-1996_08
Patent number
US05547606

Reaction notes

Loading…