反应详情

A suspension of 45.3 g of diethyl (2,4,5-trifluoro-3-methyl-6-nitrobenzoyl)malonate and 30 mg of p-toluenesulfonic acid in 120 ml of water was heated at reflux for 50 minutes. After cooling, the reaction mixture was extracted with diethyl ether. The combined organic extracts were washed with brine, dried and evaporated to give 34.2 g of the desired compound as brown oil.

1. temperaturewas heated
2. temperatureat reflux for 50 minutes
3. temperatureAfter cooling
4. extractionthe reaction mixture was extracted with diethyl ether
5. washThe combined organic extracts were washed with brine
6. customdried
7. customevaporated