4,6-Dichloro-N-(1,1-dimethylethyl)-2-pyrimidinamine → HCID 19428515, compound

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Reaction Steps

A solution of 5.0 g 4,6-dichloro-2-(1,1-dimethylethylamino)pyrimidine in 25 ml of 1-amino-1,1-dimethylethane is heated in a closed tube at 130° C. for 15 hours. Then, the reaction mixture is evaporated and the residue is distributed between 80 ml of chloroform and 15 ml of 10% sodium hydroxide solution. After separation the organic phase is washed 4 times with 20 ml of water each, then dried and evaporated. After recrystallization from hexane the title compound is obtained in a yield of 5.45 g (93.4%), m.p.:128°-130° C.

Provenance & Evidence