4,6-Dichloro-N-(1,1-dimethylethyl)-2-pyrimidinamine → HCID 19428515, compound

HRID 1078280Notes

Reaction equation

HRID 1078280 reaction equation
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([NH:9][C:10]([CH3:13])([CH3:12])[CH3:11])[N:3]=1>NC(C)(C)C>[CH3:11][C:10]([NH:9][C:4]1[N:5]=[C:6]([Cl:8])[CH:7]=[C:2]([NH:9][C:10]([CH3:13])([CH3:12])[CH3:11])[N:3]=1)([CH3:13])[CH3:12]

Participants

3

Reactant 1

HCID 194285024,6-Dichloro-N-(1,1-dimethylethyl)-2-pyrimidinamine

Product 1

HCID 19428515HCID 19428515, compound

Reagents, catalysts & solvents 1

HCID 6385Tert-ButylamineSolvent

Procedure

A solution of 5.0 g 4,6-dichloro-2-(1,1-dimethylethylamino)pyrimidine in 25 ml of 1-amino-1,1-dimethylethane is heated in a closed tube at 130° C. for 15 hours. Then, the reaction mixture is evaporated and the residue is distributed between 80 ml of chloroform and 15 ml of 10% sodium hydroxide solution. After separation the organic phase is washed 4 times with 20 ml of water each, then dried and evaporated. After recrystallization from hexane the title compound is obtained in a yield of 5.45 g (93.4%), m.p.:128°-130° C.

Workup

  1. customThen, the reaction mixture is evaporated
  2. customAfter separation the organic phase
  3. washis washed 4 times with 20 ml of water each,
  4. customthen dried
  5. customevaporated
  6. customAfter recrystallization from hexane the title compound
  7. customis obtained in a yield of 5.45 g (93.4%), m.p.:128°-130° C.

Sources & evidence

ORD record
ord-fb943b1acd9c49de825d9a67a89bc9fc
Source dataset
uspto-grants-1996_08
Patent number
US05547949

Reaction notes

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