反应详情

After adding in small portions 10 g of 4,6-dichloro-2-(1,1-dimethylethylamino)pyrimidine to 40 ml of pyrrolidine at a temperature below 10° C. under cooling while stirring, the reaction mixture is stirred at room temperature for 1 hour, then evaporated. After distributing the residue between 150 ml of chloroform and 30 ml of 10% sodium hydroxide solution, the organic phase is separated, washed 4 times with 50 ml of water each, then dried and evaporated. After recrystallization from ethyl acetate the title compound is obtained in a yield of 10.76 g (93%), m.p.:153°-157° C.

1. temperatureunder cooling
2. stirringthe reaction mixture is stirred at room temperature for 1 hour
3. customevaporated
4. customthe organic phase is separated
5. washwashed 4 times with 50 ml of water each,
6. customthen dried
7. customevaporated
8. customAfter recrystallization from ethyl acetate the title compound
9. customis obtained in a yield of 10.76 g (93%), m.p.:153°-157° C.