Piperazine → HCID 19428497, compound

HRID 1078286Notes

Reaction equation

HRID 1078286 reaction equation
[C:1]12([NH:11][C:12]3[N:17]=[C:16]([NH:18][C:19]45[CH2:28][CH:23]6[CH2:24][CH:25]([CH2:27][CH:21]([CH2:22]6)[CH2:20]4)[CH2:26]5)[CH:15]=[C:14](Cl)[N:13]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[NH:30]1[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1>>[C:1]12([NH:11][C:12]3[N:17]=[C:16]([NH:18][C:19]45[CH2:28][CH:23]6[CH2:24][CH:25]([CH2:27][CH:21]([CH2:22]6)[CH2:20]4)[CH2:26]5)[CH:15]=[C:14]([N:30]4[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]4)[N:13]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2

Participants

3

Reactant 2

HCID 4837PiperazineHCID 19428543HCID 19428543, compound

Product 1

HCID 19428497HCID 19428497, compoundYield 83.36%

Procedure

2,4-bis-(1-Adamantylamino)-6-chloropyrimidine is reacted with piperazine similarly as described in Example 5 to give the title compound in a yield of 83.36%, m.p.:168°-175° C.

Sources & evidence

ORD record
ord-e4dea742f48743d2925db1892dca7dcd
Source dataset
uspto-grants-1996_08
Patent number
US05547949

Reaction notes

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