Neopentylamine → HCID 19428493, compound

HRID 1078292Notes

Reaction equation

HRID 1078292 reaction equation
[NH2:1][CH2:2][C:3]([CH3:6])([CH3:5])[CH3:4].[Cl:7][C:8]1[CH:13]=[C:12](Cl)[N:11]=[C:10]([NH:15][CH2:16][C:17]([CH3:20])([CH3:19])[CH3:18])[N:9]=1>C(O)(C)C>[Cl:7][C:8]1[CH:13]=[C:12]([NH:1][CH2:2][C:3]([CH3:6])([CH3:5])[CH3:4])[N:11]=[C:10]([NH:15][CH2:16][C:17]([CH3:20])([CH3:19])[CH3:18])[N:9]=1

Participants

4

Reactant 2

HCID 79882NeopentylamineHCID 19428516HCID 19428516, compound

Product 1

HCID 19428493HCID 19428493, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

After adding 5 ml of 1-amino-2,2-dimethylpropane to a solution of 5.0 g of 4,6-dichloro-2-(2,2-dimethylpropylamino)pyrimidine in 25 ml of isopropanol the reaction mixture is boiled under reflux for 20 hours, then evaporated. The residue is distributed between 80 ml of chloroform and 15 ml of 10% sodium hydroxide solution. After separation the organic phase is washed 4 times with 20 ml of water each, then dried and evaporated. After recrystallization from hexane the title compound is obtained in a yield of 2.994 g (49.4%), m.p.:95°-98° C.

Workup

  1. temperatureunder reflux for 20 hours
  2. customevaporated
  3. customAfter separation the organic phase
  4. washis washed 4 times with 20 ml of water each,
  5. customthen dried
  6. customevaporated
  7. customAfter recrystallization from hexane the title compound
  8. customis obtained in a yield of 2.994 g (49.4%), m.p.:95°-98° C.

Sources & evidence

ORD record
ord-8d36710408eb48b587c3d9f84f146860
Source dataset
uspto-grants-1996_08
Patent number
US05547949

Reaction notes

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