HCID 19428551, compound → HCID 67769887, compound

HRID 1078299Notes

Reaction equation

[CH3:1][C@@H:2]1[CH2:34][C@@H:33]2[C@:20]([CH3:37])([CH2:21][CH:22]=[C:23]3[C@H:32]2[CH2:31][CH2:30][C:29]2[C@:24]3([CH3:36])[CH:25]=[CH:26][C:27](=[O:35])[CH:28]=2)[C@H:3]1[C:4](=[O:19])[CH2:5]OS(C1C=CC([N+]([O-])=O)=CC=1)(=O)=O.[CH2:38]1[CH2:69][O:68][C:40]2([CH2:45][CH2:44][N:43]([C:46]3[N:51]=[C:50]([N:52]4[CH2:57][CH2:56][C:55]5([O:61][CH2:60][CH2:59][O:58]5)[CH2:54][CH2:53]4)[CH:49]=[C:48]([N:62]4[CH2:67][CH2:66][NH:65][CH2:64][CH2:63]4)[N:47]=3)[CH2:42][CH2:41]2)[O:39]1>>[CH2:38]1[CH2:69][O:68][C:40]2([CH2:41][CH2:42][N:43]([C:46]3[N:51]=[C:50]([N:52]4[CH2:57][CH2:56][C:55]5([O:61][CH2:60][CH2:59][O:58]5)[CH2:54][CH2:53]4)[CH:49]=[C:48]([N:62]4[CH2:67][CH2:66][N:65]([CH2:5][C:4](=[O:19])[C@@H:3]5[C@:20]6([CH3:37])[C@H:33]([C@H:32]7[C:23](=[CH:22][CH2:21]6)[C@:24]6([CH3:36])[C:29](=[CH:28][C:27](=[O:35])[CH:26]=[CH:25]6)[CH2:30][CH2:31]7)[CH2:34][C@H:2]5[CH3:1])[CH2:64][CH2:63]4)[N:47]=3)[CH2:44][CH2:45]2)[O:39]1

Participants

Reactant 2

HCID 19428551HCID 19428551, compound

HCID 57078569HCID 57078569, compound

Product 1

HCID 67769887HCID 67769887, compoundYield 77.5%

Procedure

The reaction of 16α-methyl-21-(4-nitrobenzenesulfonyloxy)pregna-1,4,9(11)-triene-3,20-dione with 2,4-bis(4,4-ethylenedioxy-1-piperidinyl)-6-(1-piperazinyl)pyrimidine as described in Example 5 leads to the title compound in a yield of 77.5%, m.p.:156°-174° C.

Sources & evidence

ORD record: ord-890c77f5655e4314a1bd03d303e46004
Source dataset: uspto-grants-1996_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05547949

Reaction notes

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