Piperazine → HCID 19428535, compound

HRID 1078302Notes

Reaction equation

HRID 1078302 reaction equation
Cl[C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH2:10][CH2:9]2)[N:5]=[C:4]([N:13]2[C:18]([CH3:20])([CH3:19])[CH2:17][CH2:16][CH2:15][C:14]2([CH3:22])[CH3:21])[N:3]=1.[NH:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>>[CH3:20][C:18]1([CH3:19])[CH2:17][CH2:16][CH2:15][C:14]([CH3:21])([CH3:22])[N:13]1[C:4]1[N:3]=[C:2]([N:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)[CH:7]=[C:6]([N:8]2[CH2:9][CH2:10][CH2:11][CH2:12]2)[N:5]=1

Participants

3

Reactant 2

HCID 4837PiperazineHCID 19428542HCID 19428542, compound

Product 1

HCID 19428535HCID 19428535, compoundYield 80.2%

Procedure

4-chloro-2-(2,2,6,6-tetramethyl-1-piperidinyl)-6-(1-pyrrolidinyl) pyrimidine is reacted with piperazine as described in Example 5 to obtain the title compound in a yield of 80.2%, m.p.:134°-137° C.

Sources & evidence

ORD record
ord-404ef94c1f754eb3a9160ef3b27cad67
Source dataset
uspto-grants-1996_08
Patent number
US05547949

Reaction notes

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