Cyclopentylamine → HCID 19428506, compound

HRID 1078308Notes

Reaction equation

HRID 1078308 reaction equation
[CH:1]1([NH:6][C:7]2[N:12]=[C:11]([Cl:13])[CH:10]=[C:9](Cl)[N:8]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:15]1([NH2:20])[CH2:19][CH2:18][CH2:17][CH2:16]1>C(O)(C)C>[CH:1]1([NH:6][C:7]2[N:8]=[C:9]([NH:20][CH:15]3[CH2:19][CH2:18][CH2:17][CH2:16]3)[CH:10]=[C:11]([Cl:13])[N:12]=2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

4

Reactant 2

HCID 2906CyclopentylamineHCID 19428501HCID 19428501, compound

Product 1

HCID 19428506HCID 19428506, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

5.0 g of 2-(cyclopentylamino)-4,6-dichloropyrimidine are dissolved in 25 ml of isopropanol, 7.5 ml of cyclopentylamine are added thereto and the reaction mixture is boiled for 6 hours. Then the reaction mixture is evaporated, the residue is separated between 80 ml of chloroform and 15 ml of 10% sodium hydroxide solution. After separation the organic phase is washed 4 times with 20 ml of water each, then dried and evaporated. The title compound is obtained after recrystallization from hexane in a yield of 5.24 g (86.7%), m.p.:94°-98° C.

Workup

  1. customThen the reaction mixture is evaporated
  2. customthe residue is separated between 80 ml of chloroform and 15 ml of 10% sodium hydroxide solution
  3. customAfter separation the organic phase
  4. washis washed 4 times with 20 ml of water each,
  5. customthen dried
  6. customevaporated

Sources & evidence

ORD record
ord-2d5ac01b10e64d03b908b5a704a62cb1
Source dataset
uspto-grants-1996_08
Patent number
US05547949

Reaction notes

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