HuagongsheHuagongshe Chemistry Print Report · For research reference only
P-Chloroacetophenone → N-[1-(4-chlorophenyl)ethyl]-3-(2,4-dimethylimidazol-1-yl)propylamine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | P-Chloroacetophenone | HCID 7467 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 2,4-dimethyl-1H-imidazole-1-propanamine | HCID 13588910 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-[1-(4-chlorophenyl)ethyl]-3-(2,4-dimethylimidazol-1-yl)propylamine dihydrochloride | HCID 19429532 | — |
Reaction Steps
In a similar manner to Example 1, a mixture of 4'-chloroacetophenone (4.0 g) and 1-(3-aminopropyl)-2,4-dimethylimidazole (4.0 g) was heated at 115°-120° C. for 7 hours then reduced with sodium borohydride (2.0 g) in ethanol (70 ml) over 18 hours. The solid obtained was triturated with propan-2-ol and filtered to give N-[1-(4-chlorophenyl)ethyl]-3-(2,4-dimethylimidazol-1-yl)propylamine dihydrochloride, m.p. 218°-220° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05547972 |
| Source dataset | uspto-grants-1996_08 |
| ORD ID | ord-2671ebec801b435e9eafb03be4b036bf |
| Source note | uspto-grants-1996_08 |