反应详情

In a similar manner to Example 1, a mixture of 4'-chloroacetophenone (4.0 g) and 1-(3-aminopropyl)-2,4-dimethylimidazole (4.0 g) was heated at 115°-120° C. for 7 hours then reduced with sodium borohydride (2.0 g) in ethanol (70 ml) over 18 hours. The solid obtained was triturated with propan-2-ol and filtered to give N-[1-(4-chlorophenyl)ethyl]-3-(2,4-dimethylimidazol-1-yl)propylamine dihydrochloride, m.p. 218°-220° C.

1. temperaturewas heated at 115°-120° C. for 7 hours
2. customThe solid obtained
3. customwas triturated with propan-2-ol
4. filtrationfiltered