4-Chlorobenzaldehyde → N-(4-chlorobenzyl)-3-(2,4-dimethylimidazol-1-yl)propylamine dihydrochloride

Participants

Reaction Steps

In a similar manner to Example 35, a mixture of 4-chlorobenzaldehyde (3.8 g) and 1-(3-aminopropyl)-2,4-dimethylimidazole (4.1 g) in ethanol (70 ml) was stirred and then reduced with sodium borohydride (2.0 g). The hydrochloride salt was triturated with propan-2-ol, filtered and the residue washed with ether, then dried under vacuum at 45° C., to give N-(4-chlorobenzyl)-3-(2,4-dimethylimidazol-1-yl)propylamine dihydrochloride, m.p. 208°-210° C.

Provenance & Evidence