Formaldehyde → HCID 19429368, compound

HRID 1078397Notes

Reaction equation

HRID 1078397 reaction equation
[C:1](O)(=O)C(O)=O.[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([CH:14]([NH:17][CH2:18][CH2:19][CH2:20][N:21]2[CH:25]=[CH:24][N:23]=[CH:22]2)[CH2:15][CH3:16])=[CH:10][CH:9]=1.C=O>C(O)=O>[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([CH:14]([N:17]([CH2:18][CH2:19][CH2:20][N:21]2[CH:25]=[CH:24][N:23]=[CH:22]2)[CH3:1])[CH2:15][CH3:16])=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 19429462HCID 19429462, compound2×

Product 1

HCID 19429368HCID 19429368, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Conditions

Temperature
95 °C

Procedure

n-[1-(4-Chlorophenyl)propyl]-3-(imidazol-1-yl)propylamine (13.9 g, free base of Example 30) was added in portions to formic acid (11.75 g, 98-100%) at 0° C. Formaldehyde (9.6 g, 37%) was added and the mixture heated at 95° C. for 6 hours. Work-up as described in Example 90 gave N-[1-(4-chlorophenyl)propyl]-3-(imidazol-1-yl)-N-methylpropylamine as an oil which was not distilled.

Sources & evidence

ORD record
ord-d91239fec6094b26a3de4fcc267a16f6
Source dataset
uspto-grants-1996_08
Patent number
US05547972

Reaction notes

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