Citric Acid → HCID 67588420, compound

HRID 1078403Notes

Reaction equation

HRID 1078403 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([NH:11][CH2:12][CH2:13][CH2:14][N:15]2[CH:19]=[CH:18][N:17]=[CH:16]2)([CH3:10])[CH3:9])=[CH:4][CH:3]=1.[C:20]([OH:32])(=[O:31])[CH2:21][C:22]([CH2:27][C:28]([OH:30])=[O:29])([C:24]([OH:26])=[O:25])[OH:23]>>[C:20]([OH:32])(=[O:31])[CH2:21][C:22]([CH2:27][C:28]([OH:30])=[O:29])([C:24]([OH:26])=[O:25])[OH:23].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([NH:11][CH2:12][CH2:13][CH2:14][N:15]2[CH:19]=[CH:18][N:17]=[CH:16]2)([CH3:10])[CH3:9])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 311Citric AcidHCID 9863253HCID 9863253, compound

Product 1

HCID 67588420HCID 67588420, compound

Procedure

N-[1-(4-Chlorophenyl)-1-methylethyl]-3-(imidazol-1-yl)propylamine (1.25 g) and citric acid (0.95 g) were dissolved in warm IMS (10 ml) and allowed to cool. After standing with occasional scratching a salt crystallised. The salt was collected by filtration, triturated with ethyl acetate/methanol (1:1) filtered and dried to give N-[1-(4-chlorophenyl)-1-methylethyl]-3-(imidazol-1-yl)propylamine citrate, m.p. 143°-145° C.

Workup

  1. temperatureto cool
  2. customcrystallised
  3. filtrationThe salt was collected by filtration
  4. customtriturated with ethyl acetate/methanol (1:1)
  5. filtrationfiltered
  6. customdried

Sources & evidence

ORD record
ord-176fe8cfeaad4179baa14c09c8aa8c87
Source dataset
uspto-grants-1996_08
Patent number
US05547972

Reaction notes

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