Hydrochloric Acid → (2E)-2-[2-[(3-chlorophenoxy)methyl]phenyl]-2-methoxyimino-N-methylacetamide

HRID 1078483Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1078483
CO[C:3](=[O:16])/[C:4](/[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH2:14]Br)=[N:5]/[O:6][CH3:7].[Cl:17][C:18]1[CH:19]=[C:20]([OH:24])[CH:21]=[CH:22][CH:23]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:31][NH2:32].Cl>CN(C=O)C.CO>[CH3:31][NH:32][C:3](=[O:16])/[C:4](/[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH2:14][O:24][C:20]1[CH:21]=[CH:22][CH:23]=[C:18]([Cl:17])[CH:19]=1)=[N:5]/[O:6][CH3:7]

Komponenten

8

Edukt 5

HCID 313Hydrochloric AcidHCID 6329MethylamineHCID 79333-ChlorophenolHCID 11430Potassium CarbonateHCID 10989774(E)-Methyl 2-(methoxyimino)-2-[2-(bromomethyl)phenyl]acetate

Produkt 1

HCID 22600150(2E)-2-[2-[(3-chlorophenoxy)methyl]phenyl]-2-methoxyimino-N-methylacetamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

Methyl-(E)-2-(bromomethylphenyl)-2-methoxyiminoacetate as obtained in Example 27 (1) (250 mg), 3-chlorophenol (225 mg) and potassium carbonate (482 mg) were dissolved in DMF, and the resultant mixture was stirred at room temperature for 10 hours. A solution (677 mg) of methylamine in 30% methanol was added thereto, and stirring was continued for 10 hours. The reaction mixture was neutralized with dilute hydrochloric acid, extracted with diethyl ether. The solvent was dried and evaporated, and the residue was purified by silica gel column chromatography to give 265 mg of the objective compound.

Aufarbeitung

  1. extractionextracted with diethyl ether
  2. customThe solvent was dried
  3. customevaporated
  4. customthe residue was purified by silica gel column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-5eb3620100c5433998e496ece3a1aa3b
Quelldatensatz
uspto-grants-1996_08
Patentnummer
US05548078

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