Potassium Hydroxide → HCID 10788561, compound

HRID 1078501Notes

Reaction equation

[OH-].[K+].[C:3]12([C:13]3[CH:14]=[C:15]([C:23]4[CH:24]=[C:25]5[C:30](=[CH:31][CH:32]=4)[CH:29]=[C:28]([C:33]([OH:35])=[O:34])[CH:27]=[CH:26]5)[CH:16]=[CH:17][C:18]=3[C:19]([O:21]C)=[O:20])[CH2:12][CH:7]3[CH2:8][CH:9]([CH2:11][CH:5]([CH2:6]3)[CH2:4]1)[CH2:10]2>C(O)CCC>[C:3]12([C:13]3[CH:14]=[C:15]([C:23]4[CH:24]=[C:25]5[C:30](=[CH:31][CH:32]=4)[CH:29]=[C:28]([C:33]([OH:35])=[O:34])[CH:27]=[CH:26]5)[CH:16]=[CH:17][C:18]=3[C:19]([OH:21])=[O:20])[CH2:12][CH:7]3[CH2:6][CH:5]([CH2:11][CH:9]([CH2:8]3)[CH2:10]1)[CH2:4]2

Participants

Conditions

Temperature: 110 °C

Procedure

2 g of potassium hydroxide are added to a solution of 1.20 g (2.72 mmol) of the diester obtained in Example 15 in 50 ml of n-butanol and the mixture is heated at 110° C. for 24 hours. After the same treatment as in Example 8, and recrystallization from the ethyl acetate-THF mixture, 605 mg (52%) of the expected derivative are isolated, which derivative melts at 333°-335° C.

Workup

customAfter the same treatment as in Example 8, and recrystallization from the ethyl acetate-THF mixture, 605 mg (52%) of the expected
customderivative are isolated

Sources & evidence

ORD record: ord-6d81d3e161b64b5286cb0add185246ac
Source dataset: uspto-grants-1996_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05547983

Reaction notes

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