HCID 10626406, compound → HCID 10389354, compound

HRID 1078511Notes

Reaction equation

HRID 1078511 reaction equation
[C:1]12([C:11]3[CH:12]=[C:13]([C:22]4[CH:23]=[C:24]5[C:29](=[CH:30][CH:31]=4)[CH:28]=[C:27]([C:32]([O:34]CC4C=CC=CC=4)=[O:33])[CH:26]=[CH:25]5)[CH:14]=[CH:15][C:16]=3[CH2:17][CH:18]([OH:21])[CH2:19][OH:20])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2>O1CCOCC1.[Pd]>[C:1]12([C:11]3[CH:12]=[C:13]([C:22]4[CH:23]=[C:24]5[C:29](=[CH:30][CH:31]=4)[CH:28]=[C:27]([C:32]([OH:34])=[O:33])[CH:26]=[CH:25]5)[CH:14]=[CH:15][C:16]=3[CH2:17][CH:18]([OH:21])[CH2:19][OH:20])[CH2:10][CH:5]3[CH2:4][CH:3]([CH2:9][CH:7]([CH2:6]3)[CH2:8]1)[CH2:2]2

Participants

4

Reactant 1

HCID 10626406HCID 10626406, compound

Product 1

HCID 10389354HCID 10389354, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 312751,4-DioxaneSolvent

Procedure

4 g (7.32 mmol) of the ester obtained in Example 46, in solution in 100 ml of dioxane, are hydrogenated in the presence of 1.20 g of palladium on carbon (10%) under a hydrogen pressure of 7 bar, for 5 h at 50° C. After the same treatment as in Example 5, followed by a recrystallization from the ethanol/water mixture, 3 g (90%) of the expected derivative are isolated, which derivative melts at 258° C.

Workup

  1. customAfter the same treatment as in Example 5, followed by a recrystallization from the ethanol/water mixture, 3 g (90%) of the expected
  2. customderivative are isolated

Sources & evidence

ORD record
ord-226381f843774247a853351a46913b36
Source dataset
uspto-grants-1996_08
Patent number
US05547983

Reaction notes

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