Sodium Hydroxide → HCID 19429720, compound

HRID 1078513Notes

Reaction equation

HRID 1078513 reaction equation
[C:1]12([C:11]3[CH:12]=[C:13]([C:22]4[CH:23]=[C:24]5[C:29](=[CH:30][CH:31]=4)[CH:28]=[C:27]([C:32]([O:34]CC4C=CC=CC=4)=[O:33])[CH:26]=[CH:25]5)[CH:14]=[CH:15][C:16]=3[C:17](=[O:21])[N:18]([CH3:20])[CH3:19])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[OH-].[Na+]>CO>[C:1]12([C:11]3[CH:12]=[C:13]([C:22]4[CH:23]=[C:24]5[C:29](=[CH:30][CH:31]=4)[CH:28]=[C:27]([C:32]([OH:34])=[O:33])[CH:26]=[CH:25]5)[CH:14]=[CH:15][C:16]=3[C:17](=[O:21])[N:18]([CH3:19])[CH3:20])[CH2:10][CH:5]3[CH2:4][CH:3]([CH2:9][CH:7]([CH2:6]3)[CH2:8]1)[CH2:2]2

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 19429704HCID 19429704, compound

Product 1

HCID 19429720HCID 19429720, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

990 mg (2.11 mmol) of this ester, in 25 ml of methanol, are treated with 2 g of sodium hydroxide. The reaction mixture is refluxed for 1 h and it is then treated as in Example 3. After recrystallization from absolute ethanol, 630 mg (66%) of the expected product are isolated, which product melts at 318°-320° C.

Workup

  1. temperatureThe reaction mixture is refluxed for 1 h
  2. additionit is then treated as in Example 3
  3. customAfter recrystallization from absolute ethanol, 630 mg (66%) of the expected product
  4. customare isolated

Sources & evidence

ORD record
ord-d0651feda869468fb528e12b890b6b81
Source dataset
uspto-grants-1996_08
Patent number
US05547983

Reaction notes

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