Dimethylamine → HCID 19427683, compound

HRID 1078547Notes

Reaction equation

HRID 1078547 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH3:27])[C:5]2[N:6]=[C:7](OS(C(F)(F)F)(=O)=O)[C:8]3[CH:18]=[CH:17][CH:16]=[N:15][C:9]=3[N:10]([CH2:13][CH3:14])[C:11]=2[N:12]=1.[CH3:28][NH:29][CH3:30]>C(OCC)(=O)C>[CH3:1][C:2]1[CH:3]=[C:4]([CH3:27])[C:5]2[N:6]=[C:7]([N:29]([CH3:30])[CH3:28])[C:8]3[CH:18]=[CH:17][CH:16]=[N:15][C:9]=3[N:10]([CH2:13][CH3:14])[C:11]=2[N:12]=1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 19427674HCID 19427674, compound

Product 1

HCID 19427683HCID 19427683, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 2,4-dimethyl-11-ethyl-6-trifluoromethanesulfonyloxy-11H-dipyrido[3,2-b:2',3'-e][1,4]diazepine (0.3 g, 0.75 mmole) and dimethylamine (excess, used as solvent) were placed in a sealed pressure tube and left at room temperature for 3 days. The reaction mixture was diluted with ethyl acetate, washed with water, dried, filtered and concentrated. The 260 mg of product thus obtained was recrystallized from ethyl acetate/hexane to give the title compound, m.p. 150°-152° C.

Workup

  1. customwere placed in a sealed pressure tube
  2. washwashed with water
  3. customdried
  4. filtrationfiltered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-bc1b72c6c3534deab72d90dd61448f66
Source dataset
uspto-grants-1996_08
Patent number
US05550117

Reaction notes

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