反应详情

To a suspension of 3-nitro-6,9-dimethylpyrido[2,3-b][1,5]benzoxazepin-5(6H)-one (1.6 g, 5.6 mmol) in acetic acid (30 ml) was added a solution of stannous chloride dihydrate (10 g, 44 mmol) in conc. hydrochloric acid (13 ml). After stirring the mixture for 3 hours, the precipitated product was filtered and washed with ether. The product was then dissolved in water, basified with 2N sodium hydroxide, extracted with ether and ethyl acetate, dried (anhydrous magnesium sulfate), and concentrated. Crystallization from ethanol/hexane provided 0.82 g (57% of theory) of pure product as tan needles, m.p. 191°-193° C.

1. filtrationthe precipitated product was filtered
2. washwashed with ether
3. dissolutionThe product was then dissolved in water
4. extractionextracted with ether and ethyl acetate
5. dry with materialdried (anhydrous magnesium sulfate)
6. concentrationconcentrated
7. customCrystallization from ethanol/hexane
8. customprovided 0.82 g (57% of theory) of pure product as tan needles, m.p. 191°-193° C.