Thionyl Chloride → HCID 15290962, compound

HRID 1078558Notes

Reaction equation

HRID 1078558 reaction equation
[F:1][C:2]([F:25])([F:24])[C:3]1[CH:4]=[C:5]([CH:21]=[CH:22][CH:23]=1)[C:6]([N:8]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[O:11][CH2:10][CH:9]1[CH2:18][CH2:19]O)=[O:7].S(Cl)([Cl:28])=O>ClCCl>[Cl:28][CH2:19][CH2:18][CH:9]1[N:8]([C:6](=[O:7])[C:5]2[CH:21]=[CH:22][CH:23]=[C:3]([C:2]([F:25])([F:24])[F:1])[CH:4]=2)[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[O:11][CH2:10]1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 19428106HCID 19428106, compound

Product 1

HCID 15290962HCID 15290962, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 21.93 g of (±)-4-[3-(trifluoromethyl)benzoyl]-3,4-dihydro-2H-1,4-benzoxazine-3-ethanol dissolved in 280 ml of dichloromethane are added 18 ml (0.248 mol) of thionyl chloride and the mixture is stirred at room temperature for 6 h.

Sources & evidence

ORD record
ord-5b065eff6d3a47ecb759eb0577d50d73
Source dataset
uspto-grants-1996_08
Patent number
US05550125

Reaction notes

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