Thionyl Chloride → HCID 15290963, compound

HRID 1078561Notes

Reaction equation

HRID 1078561 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[O:10][CH2:9][CH:8]([CH2:11][CH2:12]O)[N:7]([C:14](=[O:25])[C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[CH:16]=3)[C:6]=2[CH:26]=1.S(Cl)([Cl:29])=O>ClCCl>[Cl:29][CH2:12][CH2:11][CH:8]1[N:7]([C:14](=[O:25])[C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[CH:16]=2)[C:6]2[CH:26]=[C:2]([F:1])[CH:3]=[CH:4][C:5]=2[O:10][CH2:9]1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 19428113HCID 19428113, compound

Product 1

HCID 15290963HCID 15290963, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 11.27 g (0.031 mol) of (±)-6-fluoro-4-[3-(trifluoromethyl)benzoyl]-3,4-dihydro-2H-1,4-benzoxazine-3-ethanol dissolved in 140 ml of dichloromethane are added 9 ml (0.124 mol) of thionyl chloride and the mixture is stirred at room temperature for 5 h.

Sources & evidence

ORD record
ord-5f1f6ed2b7894a7aa707e30c3b4e5155
Source dataset
uspto-grants-1996_08
Patent number
US05550125

Reaction notes

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