Thionyl Chloride → HCID 15290966, compound

HRID 1078564Notes

Reaction equation

HRID 1078564 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[O:11][CH2:10][CH:9]([CH2:12][CH2:13]O)[N:8]([C:15](=[O:26])[C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:25])([F:24])[F:23])[CH:17]=3)[C:7]=2[CH:27]=1.S(Cl)([Cl:30])=O>ClCCl>[Cl:30][CH2:13][CH2:12][CH:9]1[N:8]([C:15](=[O:26])[C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:25])([F:24])[F:23])[CH:17]=2)[C:7]2[CH:27]=[C:3]([O:2][CH3:1])[CH:4]=[CH:5][C:6]=2[O:11][CH2:10]1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 19428104HCID 19428104, compound

Product 1

HCID 15290966HCID 15290966, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 14.74 g (0.039 mol) of (±)-6-methoxy-4-[3-(trifluoromethyl)benzoyl]-3,4-dihydro-2H-1,4-benzoxazine-3-ethanol dissolved in 165 ml of dichloromethane are added 14 ml (0.19 mol) of thionyl chloride and the mixture is stirred at room temperature for 5 h.

Sources & evidence

ORD record
ord-b678b4ea89bd4d4ab1866a18a8d8cad9
Source dataset
uspto-grants-1996_08
Patent number
US05550125

Reaction notes

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