1-Phenylpiperazine → 5,7-dimethoxy-4-methyl-3-[2-(4-phenyl-1-piperazinyl)ethyl]-2H-1-benzopyran-2-one

HRID 1078589Notes

Reaction equation

HRID 1078589 reaction equation
CS(O[CH2:6][CH2:7][C:8]1[C:9](=[O:23])[O:10][C:11]2[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[C:15]([O:21][CH3:22])[C:12]=2[C:13]=1[CH3:14])(=O)=O.[C:24]1([N:30]2[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]2)[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>C(O)(C)C.CC(OC)(C)C>[CH3:22][O:21][C:15]1[C:12]2[C:13]([CH3:14])=[C:8]([CH2:7][CH2:6][N:33]3[CH2:34][CH2:35][N:30]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[CH2:31][CH2:32]3)[C:9](=[O:23])[O:10][C:11]=2[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=1

Participants

4

Reactant 2

HCID 70961-PhenylpiperazineHCID 194281303-[2-(methanesulphonyloxy)ethyl]-5,7-dimethoxy-4-methyl-2H-1-benzopyran-2-one

Product 1

HCID 194281295,7-dimethoxy-4-methyl-3-[2-(4-phenyl-1-piperazinyl)ethyl]-2H-1-benzopyran-2-oneYield 50%

Reagents, catalysts & solvents 1

HCID 86616950TBME isopropanolSolvent

Procedure

Process B; starting materials: 3-[2-(methanesulphonyloxy)ethyl]-5,7-dimethoxy-4-methyl-2H-1-benzopyran-2-one (Example 35) and 1-phenylpiperazine; yield 50%; m.p. 112°-114° C. (from isopropanol/TBME).

Sources & evidence

ORD record
ord-71d2c85c10104e319528c924195b4206
Source dataset
uspto-grants-1996_08
Patent number
US05550129

Reaction notes

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