1-(2-Ethoxyphenyl)piperazine → 3-{2-[4-(2-ethoxyphenyl)-1-piperazinyl]ethyl}-5,7-dimethoxy-4-methyl-2H-1-benzopyran-2-one

HRID 1078594Notes

Reaction equation

HRID 1078594 reaction equation
Cl[CH2:2][CH2:3][C:4]1[C:5](=[O:19])[O:6][C:7]2[CH:14]=[C:13]([O:15][CH3:16])[CH:12]=[C:11]([O:17][CH3:18])[C:8]=2[C:9]=1[CH3:10].[CH2:20]([O:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[N:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1)[CH3:21]>>[CH2:20]([O:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[N:29]1[CH2:30][CH2:31][N:32]([CH2:2][CH2:3][C:4]2[C:5](=[O:19])[O:6][C:7]3[CH:14]=[C:13]([O:15][CH3:16])[CH:12]=[C:11]([O:17][CH3:18])[C:8]=3[C:9]=2[CH3:10])[CH2:33][CH2:34]1)[CH3:21]

Participants

3

Reactant 2

HCID 833571-(2-Ethoxyphenyl)piperazineHCID 194281613-(2-chloroethyl)-5,7-dimethoxy-4-methyl-2H-1-benzopyran-2-one

Product 1

HCID 194281373-{2-[4-(2-ethoxyphenyl)-1-piperazinyl]ethyl}-5,7-dimethoxy-4-methyl-2H-1-benzopyran-2-oneYield 31%

Procedure

Process B: starting materials: 3-(2-chloroethyl)-5,7-dimethoxy-4-methyl-2H-1-benzopyran-2-one (Example 39) and 1-(2-ethoxyphenyl)piperazine; yield 31% of crude product.

Sources & evidence

ORD record
ord-2886c4eb72fa42749201d06ff52c2639
Source dataset
uspto-grants-1996_08
Patent number
US05550129

Reaction notes

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