1-(3-(Trifluoromethyl)phenyl)piperazine → 5,7-dimethoxy-4-methyl-3-{2-[4-(3-trifluoromethylphenyl)-1-piperazinyl]ethyl}-2H-1-benzopyran-2-one

HRID 1078597Notes

Reaction equation

HRID 1078597 reaction equation
Cl[CH2:2][CH2:3][C:4]1[C:5](=[O:19])[O:6][C:7]2[CH:14]=[C:13]([O:15][CH3:16])[CH:12]=[C:11]([O:17][CH3:18])[C:8]=2[C:9]=1[CH3:10].[F:20][C:21]([F:35])([F:34])[C:22]1[CH:23]=[C:24]([N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)[CH:25]=[CH:26][CH:27]=1>C(O)(C)C>[CH3:18][O:17][C:11]1[C:8]2[C:9]([CH3:10])=[C:4]([CH2:3][CH2:2][N:31]3[CH2:30][CH2:29][N:28]([C:24]4[CH:25]=[CH:26][CH:27]=[C:22]([C:21]([F:34])([F:35])[F:20])[CH:23]=4)[CH2:33][CH2:32]3)[C:5](=[O:19])[O:6][C:7]=2[CH:14]=[C:13]([O:15][CH3:16])[CH:12]=1

Participants

4

Reactant 2

HCID 42961-(3-(Trifluoromethyl)phenyl)piperazineHCID 194281613-(2-chloroethyl)-5,7-dimethoxy-4-methyl-2H-1-benzopyran-2-one

Product 1

HCID 194281675,7-dimethoxy-4-methyl-3-{2-[4-(3-trifluoromethylphenyl)-1-piperazinyl]ethyl}-2H-1-benzopyran-2-oneYield 47%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Process B; starting materials: 3-(2-chloroethyl)-5,7-dimethoxy-4-methyl-2H-1-benzopyran-2-one (Example 39) and 1-(3-trifluoromethylphenyl)piperazine; yield 47%; m.p. 138°-139° C. (from isopropanol).

Sources & evidence

ORD record
ord-9e2494fbeab2428ca06a1ba639d89e6f
Source dataset
uspto-grants-1996_08
Patent number
US05550129

Reaction notes

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