HCID 67690831, compound → HCID 9926785, compound

HRID 1078702Notes

Reaction equation

HRID 1078702 reaction equation
C[O:2][C:3](=[O:24])[CH2:4][CH2:5][C:6]1[CH:23]=[CH:22][C:9]2[C:10]([OH:21])=[C:11]([CH2:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH2:12][O:13][C:8]=2[CH:7]=1>CO>[OH:21][C@@H:10]1[C:9]2[CH:22]=[CH:23][C:6]([CH2:5][CH2:4][C:3]([OH:24])=[O:2])=[CH:7][C:8]=2[O:13][CH2:12][C@H:11]1[CH2:14][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

3

Reactant 1

HCID 67690831HCID 67690831, compound

Product 1

HCID 9926785HCID 9926785, compoundYield 30%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using the procedure of Example 2G with methanol as solvent at room temperature, the compound of step A (700 mg, 2.16 mmole) was reduced and the trans isomer 4-hydroxy-3-phenylmethyl-2H-1-benzopyran-7-propionic acid methyl ester saponified using the procedure of Example 2I to give the title compound (210 mg), 30% yield.

Workup

  1. customat room temperature

Sources & evidence

ORD record
ord-056c1f2e592a41c29f5da65e4f2ac03b
Source dataset
uspto-grants-1996_08
Patent number
US05550152

Reaction notes

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