反应详情

温度

130 °C

A solution containing 5.0 g of 4,6-dichloro-2-(1,1-dimethylethylamino)pyrimidine in 25 ml of 1-amino-1,1-dimethylethane is heated in a closed tube at 130° C. for 15 hours. Thereafter, the reaction mixture is evaporated and the evaporation residue is distributed between 80 ml of chloroform and 15 ml of 10% sodium hydroxide solution. After separation the organic phase is washed 4 times with 20 ml of water each, then dried and evaporated. The evaporation residue is recrystallized from hexane to give the title compound in a yield of 5.45 g (93.4%), m.p.: 128°-130° C.

1. customThereafter, the reaction mixture is evaporated
2. customAfter separation the organic phase
3. washis washed 4 times with 20 ml of water each,
4. customthen dried
5. customevaporated
6. customThe evaporation residue is recrystallized from hexane