4,6-Dichloro-N-(1,1-dimethylethyl)-2-pyrimidinamine → HCID 19428515, compound

HRID 1078937Notes

Reaction equation

HRID 1078937 reaction equation
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([NH:9][C:10]([CH3:13])([CH3:12])[CH3:11])[N:3]=1>NC(C)(C)C>[Cl:8][C:6]1[CH:7]=[C:2]([NH:9][C:10]([CH3:13])([CH3:12])[CH3:11])[N:3]=[C:4]([NH:9][C:10]([CH3:13])([CH3:12])[CH3:11])[N:5]=1

Participants

3

Reactant 1

HCID 194285024,6-Dichloro-N-(1,1-dimethylethyl)-2-pyrimidinamine

Product 1

HCID 19428515HCID 19428515, compound

Reagents, catalysts & solvents 1

HCID 6385Tert-ButylamineSolvent

Conditions

Temperature
130 °C

Procedure

A solution containing 5.0 g of 4,6-dichloro-2-(1,1-dimethylethylamino)pyrimidine in 25 ml of 1-amino-1,1-dimethylethane is heated in a closed tube at 130° C. for 15 hours. Thereafter, the reaction mixture is evaporated and the evaporation residue is distributed between 80 ml of chloroform and 15 ml of 10% sodium hydroxide solution. After separation the organic phase is washed 4 times with 20 ml of water each, then dried and evaporated. The evaporation residue is recrystallized from hexane to give the title compound in a yield of 5.45 g (93.4%), m.p.: 128°-130° C.

Workup

  1. customThereafter, the reaction mixture is evaporated
  2. customAfter separation the organic phase
  3. washis washed 4 times with 20 ml of water each,
  4. customthen dried
  5. customevaporated
  6. customThe evaporation residue is recrystallized from hexane

Sources & evidence

ORD record
ord-0b1e1bf2c8084832ad4645e5a13a6721
Source dataset
uspto-grants-1996_08
Patent number
US05550240

Reaction notes

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