Neopentylamine → HCID 19428509, compound

HRID 1078942Notes

Reaction equation

HRID 1078942 reaction equation
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([NH:9][C:10]([CH3:13])([CH3:12])[CH3:11])[N:3]=1.[NH2:14][CH2:15][C:16]([CH3:19])([CH3:18])[CH3:17]>C(O)(C)C>[Cl:8][C:6]1[N:5]=[C:4]([NH:9][C:10]([CH3:13])([CH3:12])[CH3:11])[N:3]=[C:2]([NH:14][CH2:15][C:16]([CH3:19])([CH3:18])[CH3:17])[CH:7]=1

Participants

4

Reactant 2

HCID 79882NeopentylamineHCID 194285024,6-Dichloro-N-(1,1-dimethylethyl)-2-pyrimidinamine

Product 1

HCID 19428509HCID 19428509, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

After dissolving 5.0 g of 4,6-dichloro-2-(1,1-dimethylethylamino)pyrimidine in 25 ml of isopropanol and adding 5 ml of 1-amino-2,2-dimethylpropane the reaction mixture is boiled under reflux for 20 hours. Then, the reaction mixture is evaporated and the residue is distributed between 80 ml of chloroform and 15 ml of 10% sodium hydroxide solution. After separation the organic phase is washed 4 times with 20 ml of water each, then dried and evaporated. After recrystallizing the evaporation residue from hexane the title product is obtained in a yield of 4.49 g (73%), m.p.: 109.5°-111° C.

Workup

  1. temperatureunder reflux for 20 hours
  2. customThen, the reaction mixture is evaporated
  3. customAfter separation the organic phase
  4. washis washed 4 times with 20 ml of water each,
  5. customthen dried
  6. customevaporated
  7. customAfter recrystallizing the evaporation residue from hexane the title product
  8. customis obtained in a yield of 4.49 g (73%), m.p.: 109.5°-111° C.

Sources & evidence

ORD record
ord-d99c7532bdd0478aa535651bb1db96bb
Source dataset
uspto-grants-1996_08
Patent number
US05550240

Reaction notes

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