Piperazine → HCID 19428553, compound

HRID 1078943Notes

Reaction equation

HRID 1078943 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH:8][C:9]([CH3:12])([CH3:11])[CH3:10])[N:5]=[C:4]([NH:13][CH2:14][C:15]([CH3:18])([CH3:17])[CH3:16])[CH:3]=1.[NH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[CH3:10][C:9]([NH:8][C:6]1[N:5]=[C:4]([NH:13][CH2:14][C:15]([CH3:18])([CH3:17])[CH3:16])[CH:3]=[C:2]([N:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)[N:7]=1)([CH3:12])[CH3:11]

Participants

3

Reactant 2

HCID 4837PiperazineHCID 19428509HCID 19428509, compound

Product 1

HCID 19428553HCID 19428553, compoundYield 86%

Procedure

By reacting 6-chloro-2-(1,1-dimethylethylamino)-4-(2,2-dimethylpropylamino)pyrimidine with piperazine as described in Example 4, the title product is obtained in a yield of 86.0%, m.p.: 120°-124° C.

Sources & evidence

ORD record
ord-36f479e069184b71a1fc89d232900522
Source dataset
uspto-grants-1996_08
Patent number
US05550240

Reaction notes

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