Piperazine → HCID 19428548, compound

HRID 1078945Notes

Reaction equation

Cl[C:2]1[CH:7]=[C:6]([NH:8][C:9]([CH3:12])([CH3:11])[CH3:10])[N:5]=[C:4]([NH:13][CH2:14][C:15]([CH3:18])([CH3:17])[CH3:16])[N:3]=1.[NH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[CH3:10][C:9]([NH:8][C:6]1[CH:7]=[C:2]([N:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)[N:3]=[C:4]([NH:13][CH2:14][C:15]([CH3:18])([CH3:17])[CH3:16])[N:5]=1)([CH3:12])[CH3:11]

Participants

Reactant 2

HCID 4837Piperazine

HCID 19428494HCID 19428494, compound

Product 1

HCID 19428548HCID 19428548, compoundYield 82.3%

Procedure

The reaction of 4-chloro-6-(1,1-dimethylethylamino)-2-(2,2-dimethylpropylamino)pyrimidine with piperazine as described in Example 4 gives the title product in a yield of 82.3%, m.p.: 146°-148° C.

Sources & evidence

ORD record: ord-b70f1c5283474c0384f9c5419ca70c3b
Source dataset: uspto-grants-1996_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05550240

Reaction notes

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