Piperazine → HCID 19428521, compound

HRID 1078946Notes

Reaction equation

HRID 1078946 reaction equation
Cl[C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH2:10][CH2:9]2)[N:5]=[C:4]([NH:13][C:14]([CH3:17])([CH3:16])[CH3:15])[N:3]=1.[NH:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1>>[CH3:15][C:14]([NH:13][C:4]1[N:3]=[C:2]([N:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH2:10][CH2:9]2)[N:5]=1)([CH3:17])[CH3:16]

Participants

3

Reactant 2

HCID 4837PiperazineHCID 19428541HCID 19428541, compound

Product 1

HCID 19428521HCID 19428521, compoundYield 78.1%

Procedure

The reaction of 4-chloro-2-(1,1-dimethylethylamino)-6-pyrrolidinopyrimidine with piperazine as described in Example 4 gives the title product in a yield of 78.1%, m.p.: 162°-165° C.

Sources & evidence

ORD record
ord-79f8e931b1784da78b2e4aebb04f99b5
Source dataset
uspto-grants-1996_08
Patent number
US05550240

Reaction notes

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