Piperazine → HCID 19428533, compound

HRID 1078948Notes

Reaction equation

HRID 1078948 reaction equation
Cl[C:2]1[CH:7]=[C:6]([NH:8][C:9]([CH3:12])([CH3:11])[CH3:10])[N:5]=[C:4]([N:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)[N:3]=1.[NH:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1>>[CH3:10][C:9]([NH:8][C:6]1[CH:7]=[C:2]([N:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[N:3]=[C:4]([N:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)[N:5]=1)([CH3:12])[CH3:11]

Participants

3

Reactant 2

HCID 4837PiperazineHCID 19428532HCID 19428532, compound

Product 1

HCID 19428533HCID 19428533, compoundYield 67.5%

Procedure

4-Chloro-6-(1,1-dimethylethylamino)-2-pyrrolidinopyrimidine is reacted with piperazine as described in Example 4 to give the title product in a yield of 67.5%, m.p.: 140°-145° C.

Sources & evidence

ORD record
ord-d82f3d5254f0491993e9d0bcecaf01cf
Source dataset
uspto-grants-1996_08
Patent number
US05550240

Reaction notes

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