Piperazine → HCID 19428544, compound

HRID 1078951Notes

Reaction equation

HRID 1078951 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH:8][CH2:9][C:10]([CH3:13])([CH3:12])[CH3:11])[CH:5]=[C:4]([NH:14][CH2:15][C:16]([CH3:19])([CH3:18])[CH3:17])[N:3]=1.[NH:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[CH3:17][C:16]([CH3:19])([CH3:18])[CH2:15][NH:14][C:4]1[CH:5]=[C:6]([NH:8][CH2:9][C:10]([CH3:13])([CH3:12])[CH3:11])[N:7]=[C:2]([N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)[N:3]=1

Participants

3

Reactant 2

HCID 4837PiperazineHCID 19428534HCID 19428534, compound

Product 1

HCID 19428544HCID 19428544, compoundYield 78.3%

Procedure

The reaction of 2-chloro-4,6-bis(2,2-dimethylpropylamino)pyrimidine with piperazine as described in Example 4 leads to the title product in a yield of 78.3%, m.p.: 132°-136° C.

Sources & evidence

ORD record
ord-030d0cae5667498da4d8aabb1ffb0900
Source dataset
uspto-grants-1996_08
Patent number
US05550240

Reaction notes

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