Pyrrolidine → HCID 19428550, compound

HRID 1078953Notes

Reaction equation

HRID 1078953 reaction equation
Cl[C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4]([NH:9][CH2:10][C:11]([CH3:14])([CH3:13])[CH3:12])[N:3]=1.[NH:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1>>[Cl:8][C:6]1[CH:5]=[C:4]([NH:9][CH2:10][C:11]([CH3:14])([CH3:13])[CH3:12])[N:3]=[C:2]([N:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)[N:7]=1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 19428510HCID 19428510, compound

Product 1

HCID 19428550HCID 19428550, compoundYield 75%

Procedure

The reaction of 2,4-dichloro-6-(2,2-dimethylpropylamino)pyrimidine with pyrrolidine as described in Example 12 affords the title compound in a yield of 75.0%, m.p.: 130°-135° C.

Sources & evidence

ORD record
ord-921c645f01cd4bb3b90473df471d4b4d
Source dataset
uspto-grants-1996_08
Patent number
US05550240

Reaction notes

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