Piperazine → HCID 19428549, compound

HRID 1078954Notes

Reaction equation

Cl[C:2]1[CH:7]=[C:6]([NH:8][CH2:9][C:10]([CH3:13])([CH3:12])[CH3:11])[N:5]=[C:4]([N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)[N:3]=1.[NH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[CH3:11][C:10]([CH3:13])([CH3:12])[CH2:9][NH:8][C:6]1[CH:7]=[C:2]([N:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)[N:3]=[C:4]([N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)[N:5]=1

Participants

Reactant 2

HCID 4837Piperazine

HCID 19428550HCID 19428550, compound

Product 1

HCID 19428549HCID 19428549, compoundYield 76%

Procedure

The reaction of 4-chloro-6-(2,2-dimethylpropylamino)-2-pyrrolidinopyrimidine with piperazine as described in Example 4 gives the title compound in a yield of 76.0%, m.p.: 140°-145° C.

Sources & evidence

ORD record: ord-07e9158ac88e4158b9097be1efba673b
Source dataset: uspto-grants-1996_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05550240

Reaction notes

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