Piperazine → HCID 19428552, compound

HRID 1078958Notes

Reaction equation

HRID 1078958 reaction equation
[C:1]12([NH:11][C:12]3[N:17]=[C:16](Cl)[CH:15]=[C:14]([N:19]4[CH2:23][CH2:22][CH2:21][CH2:20]4)[N:13]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[NH:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1>>[C:1]12([NH:11][C:12]3[N:17]=[C:16]([N:24]4[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]4)[CH:15]=[C:14]([N:19]4[CH2:23][CH2:22][CH2:21][CH2:20]4)[N:13]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2

Participants

3

Reactant 2

HCID 4837PiperazineHCID 19428500HCID 19428500, compound

Product 1

HCID 19428552HCID 19428552, compoundYield 69.7%

Procedure

By reacting 2-(1-adamantylamino)-4-chloro-6-pyrrolidinopyrimidine with piperazine as described in Example 4, the title compound is obtained in a yield of 69.7%, m.p.: 160°-164° C.

Sources & evidence

ORD record
ord-0bf770457f7344509b7065f14298109c
Source dataset
uspto-grants-1996_08
Patent number
US05550240

Reaction notes

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