Pyrrolidine → HCID 19428529, compound

HRID 1078959Notes

Reaction equation

HRID 1078959 reaction equation
[C:1]12([NH:11][C:12]3[CH:17]=[C:16]([Cl:18])[N:15]=[C:14](Cl)[N:13]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[NH:20]1[CH2:24][CH2:23][CH2:22][CH2:21]1>>[C:1]12([NH:11][C:12]3[CH:17]=[C:16]([Cl:18])[N:15]=[C:14]([N:20]4[CH2:24][CH2:23][CH2:22][CH2:21]4)[N:13]=3)[CH2:8][CH:7]3[CH2:9][CH:3]([CH2:4][CH:5]([CH2:6]3)[CH2:10]1)[CH2:2]2

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 19428531HCID 19428531, compound

Product 1

HCID 19428529HCID 19428529, compoundYield 80.2%

Procedure

4-(1-Adamantylamino)-2,6-dichloropyrimidine is reacted with pyrrolidine as described in Example 12 to obtain the title product in a yield of 80.2%, m.p.: 186°-190° C.

Sources & evidence

ORD record
ord-79d2a8c79f254a08a949d39aafd1d8e1
Source dataset
uspto-grants-1996_08
Patent number
US05550240

Reaction notes

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